Tetramethyl orthocarbonate → 5-(3-Bromophenyl)-2-methoxy-6,6-dimethyl-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide

HRID 339839

Reaktionsgleichung

Reaktionsgleichung von HRID 339839
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:9]([OH:12])([CH3:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[CH3:17][O:18][C:19](OC)(OC)OC>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:9]([CH3:10])([CH3:11])[O:12][C:17]([O:18][CH3:19])=[N:16][S:13]2(=[O:14])=[O:15])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 74613Tetramethyl orthocarbonateHCID 682918601-(3-Bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide

Produkt 1

HCID 683592025-(3-Bromophenyl)-2-methoxy-6,6-dimethyl-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 500 mg of 1-(3-bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide in 2 ml of tetramethoxymethane and 0.5 ml of acetic acid was stirred at 100° C. for 3 hours. After the removal of the solvent under reduced pressure, the residue (565 mg) was used in the next reaction without further purification.

Aufarbeitung

  1. customAfter the removal of the solvent under reduced pressure
  2. customthe residue (565 mg) was used in the next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-da8c1461b04e494cb05814fd65140e10
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895547B2

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