Ethyl Acetate → Methyl methyl-4-((5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethynyl)-3-methylbenzoate

HRID 340332

Reaktionsgleichung

Reaktionsgleichung von HRID 340332
Cl[C:2]1[CH:3]=[C:4]([C:10]#[C:11][C:12]2[CH:21]=[CH:20][C:15](C(OC)=O)=[CH:14][C:13]=2[CH3:22])[CH:5]=[N:6][C:7]=1[C:8]#[N:9].C[C:24]1[CH:29]=[CH:28][C:27]([NH:30]C(=O)OC(C)(C)C)=[C:26](B2OC(C)(C)C(C)(C)O2)[CH:25]=1.[CH:47]1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].[C:84]([O:87][CH2:88]C)(=[O:86])[CH3:85]>C(O)CCC.O.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH3:15][C:14]1[C:13]([CH3:22])=[C:12]([C:11]#[C:10][C:4]2[CH:5]=[N:6][C:7]3[C:8]([NH2:9])=[N:30][C:27]4[CH:26]=[C:25]([CH3:47])[CH:24]=[CH:29][C:28]=4[C:2]=3[CH:3]=2)[CH:21]=[CH:20][C:85]=1[C:84]([O:87][CH3:88])=[O:86]

Komponenten

9

Edukt 5

HCID 8857Ethyl AcetateHCID 62657Potassium Phosphate, TribasicHCID 112698722-Dicyclohexylphosphino-2',6'-dimethoxybiphenylHCID 66874787Methyl 4-((5-chloro-6-cyanopyridin-3-yl)ethynyl)-3-methylbenzoateHCID 66893267Tert-butyl 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate

Produkt 1

HCID 66892812Methyl methyl-4-((5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethynyl)-3-methylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 962WaterLösungsmittelHCID 22253497Water butanolLösungsmittel

Versuchsvorschrift

A solution of methyl 4-((5-chloro-6-cyanopyridin-3-yl)ethynyl)-3-methylbenzoate (from the previous step) (1.0 eq.), tert-butyl 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (From Example 5/Step 2) (1.5 eq.), tris(dibenzylideneacetone)dipalladium(0) (10 mol %), dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (20 mol %), and potassium phosphate (2.0 eq.) in n-butanol /H2O (2.5:1, 0.04 M) was stirred at 100° C. overnight. After cooling to ambient temperature, the reaction mixture was diluted with ethyl acetate and water. The two phases were separated, and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The crude material was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-80% ethyl acetate in hexane to give methyl methyl-4-((5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethynyl)-3-methylbenzoate as a white solid.

Aufarbeitung

  1. customwas stirred at 100° C. overnight
  2. customThe two phases were separated
  3. extractionthe aqueous layer was extracted twice with ethyl acetate
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over anhydrous MgSO4
  6. concentrationconcentrated en vacuo
  7. customThe crude material was purified by flash chromatography on a COMBIFLASH® system (ISCO)

Quellen und Nachweise

ORD-Eintrag
ord-4e8389c75db54532bda06058f79738e6
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895577B2

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