Hydrochloric Acid → HCID 178418440, Verbindung

HRID 3410

Reaktionsgleichung

Reaktionsgleichung von HRID 3410
Cl.S(OS([O-])(=O)=O)([O-])(=O)=[O:3].[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](N)=[N:18][C:16]=2[N:17]=1>O>[NH2:11][C:12]1[N:13]=[CH:14][C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([OH:3])=[N:18][C:16]=2[N:17]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 177717DisulfateHCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

Produkt 1

HCID 178418440HCID 178418440, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 2 L of concentrated HCl and 1 L of water is added 300 g of the disulfate salt of 2,7-diamino-6-phenylpyrido[2,3-d]pyrimidine and the resulting mixture refluxed with stirring overnight. The reaction mixture is cooled in an ice bath, filtered, and the insoluble product washed with water, followed by ethanol to give 149 g of the title compound 2-amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-ol, mp 390°-395° C. (darkens slowly above 350° C.).

Aufarbeitung

  1. temperaturethe resulting mixture refluxed
  2. temperatureThe reaction mixture is cooled in an ice bath
  3. filtrationfiltered
  4. washthe insoluble product washed with water

Quellen und Nachweise

ORD-Eintrag
ord-8ab3a8e6f55f47d8b365c3064b07de67
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733913

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