Water → HCID 70197022, Verbindung

HRID 342427

Reaktionsgleichung

Reaktionsgleichung von HRID 342427
[CH:1]([C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8])=[O:2].[BH4-].[Na+].O>CO>[OH:2][CH2:1][C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8]

Komponenten

5

Edukt 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 867535523-Formyl-2-methyl-7-nitrobenzo[b]furan

Produkt 1

HCID 70197022HCID 70197022, VerbindungAusbeute 74,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 3-formyl-2-methyl-7-nitrobenzo[b]furan (1.83 g) and sodium borohydride (200 mg) in methanol (40 ml) was stirred at ambient temperature for 2 hours. The reaction mixture was poured into cold water. The separated oil was extracted with dichloromethane. The extract was washed with brine, dried and evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 3-hydroxymethyl-2-methyl-7-nitrobenzo[b]furan (1.38 g) as a solid.

Aufarbeitung

  1. extractionThe separated oil was extracted with dichloromethane
  2. washThe extract was washed with brine
  3. customdried
  4. customevaporated in vacuo
  5. customThe residue was purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-37724ab1656547ecbe4ee241eb8c5182
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05858995

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