2-Phenylacetophenone → 1,2-Diphenyl-1-ethanone oxime

HRID 343089

Reaktionsgleichung

Reaktionsgleichung von HRID 343089
[C:1]1([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:17][OH:18].O.O.O.C([O-])(=O)C.[Na+]>C(O)C.O>[C:1]1([C:7](=[N:17][OH:18])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

6

Edukt 3

HCID 99482-PhenylacetophenoneHCID 443297Hydroxyamine hydrochlorideHCID 23665404Sodium Acetate Trihydrate

Produkt 1

HCID 2353831,2-Diphenyl-1-ethanone oximeAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of deoxybenzoin (407.4 g, 2.076 mol) in 2 L of absolute ethanol and 600 mL of water was treated with hydroxylamine hydrochloride (288 g, 4.15 mol) and sodium acetate trihydrate (564 g, 4.15 mol). The solution was then warmed to reflux for 2 hours. The reaction mixture was then diluted with 1000 mL of 30% aqueous ethanol and allowed to cool to room temperature whereupon crystals of pure oxime formed which were isolated by filtration and air dried to afford 415.4 g, 95%, mp 94°-96° C. of pure deoxybenzoin oxime.

Aufarbeitung

  1. temperatureThe solution was then warmed
  2. temperatureto reflux for 2 hours
  3. customformed which
  4. customwere isolated by filtration and air
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bd13a5f5f72e4db9ba33ba95fdd8b9fb
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05859257

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