8-Aminooctanoic acid → HCID 178512800, Verbindung

HRID 344653

Reaktionsgleichung

Reaktionsgleichung von HRID 344653
[CH3:1][C:2]1[CH:6]=[C:5](C)[N:4]([C:8]([NH2:10])=[NH:9])N=1.C(N(CC)C(C)C)(C)C.NCCCC[CH2:25][CH2:26][CH2:27][C:28]([OH:30])=[O:29]>O1CCOCC1.O>[NH:4]([CH2:5][CH2:6][CH2:2][CH2:1][CH2:25][CH2:26][CH2:27][C:28]([OH:30])=[O:29])[C:8]([NH2:10])=[NH:9]

Komponenten

6

Edukt 3

HCID 660858-Aminooctanoic acidHCID 81531DiisopropylethylamineHCID 975253,5-Dimethylpyrazole-1-carboxamidine

Produkt 1

HCID 178512800HCID 178512800, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3,5-dimethyl-pyrazole-1-carboxamidine (100 g; 0.5 Mole) and N,N-diisopropylethyl amine (DIEA) (65 g; 0.5 Mole) were suspended in dioxane (300 ml) and water (115 ml). 8-Amino-octanoic acid (48 cg; 0.3 Mole) was added to the mixture with stirring. The colorless solution was then refluxed for 2 days. The product was filtered and washed with water (3×50 ml).

Aufarbeitung

  1. temperatureThe colorless solution was then refluxed for 2 days
  2. filtrationThe product was filtered
  3. washwashed with water (3×50 ml)

Quellen und Nachweise

ORD-Eintrag
ord-09fff9bddcce4417857cd73a927a9c8f
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05053393

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