Ethanol → Ethyl 4-formylbenzoate

HRID 345109

Reaktionsgleichung

Reaktionsgleichung von HRID 345109
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)=[O:2].[CH3:12][CH2:13]O.CCOCC>ClCCCl>[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([O:9][CH2:12][CH3:13])=[O:8])=[CH:5][CH:4]=1)=[O:2]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 3283Diethyl EtherHCID 120884-Formylbenzoic acid

Produkt 1

HCID 80498Ethyl 4-formylbenzoateAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

A mixture of 4-formylbenzoic acid (25 g) conc sulfuric acid (2 ml) and EtOH (19.5 ml) was refluxed gently for 5 days in 100 ml of 1,2-dichloroethane. The solvent was then stripped, and Et2O was added to the residue. The Et2O solution was washed (satd aq NaHCO3) dried (Na2SO4), filtered, and evaporated. Bulb to bulb distillation afforded 20.1 g (68%) of the title ester as a clear liquid, bp 145°-150° (2,900 Pascals, 22 torr).

Aufarbeitung

  1. washThe Et2O solution was washed (satd aq NaHCO3)
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customevaporated
  5. distillationBulb to bulb distillation

Quellen und Nachweise

ORD-Eintrag
ord-5635fc28c9b1430caea087668a77e35f
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05055450

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