Carbon Dioxide → Neopeltolide

HRID 349602

Reaktionsgleichung

Reaktionsgleichung von HRID 349602
CCN([CH2:6][CH2:7][O:8][C:9]([C:11]1[CH:16]=[CH:15][C:14](N)=[CH:13][CH:12]=1)=[O:10])CC.CC1(C)S[C@@H]2[C@H](NC([CH2:30][C:31]3[CH:36]=C[CH:34]=[CH:33][CH:32]=3)=O)C(=O)N2[C@H]1C(O)=O.[OH2:41].[NH2:42][C@H:43](C(O)=O)[CH2:44][CH2:45][C:46](=[O:48])[NH2:47].C1N(C[CH2:59][OH:60])CCN(CCS(O)(=O)=O)C1.CC(NC)C1O[CH:73]([O:75][CH:76]2[CH:81](O)[CH:80]([O:83][CH:84]3[O:89]CC(O)(C)[CH:86](NC)[CH:85]3O)[CH:79](N)[CH2:78][CH:77]2N)C(N)CC1.[C:100](=O)=[O:101]>>[CH3:77][CH2:78][CH2:79][C@H:80]1[O:83][C:84](=[O:89])[CH2:85][C@@H:86]2[O:41][C@@H:33]([CH2:34][C@@H:7]([O:8][C:9](/[CH:11]=[CH:16]\[CH2:15][CH2:14][C:13]3[N:47]=[C:46](/[CH:45]=[CH:44]\[CH2:43][NH:42][C:100]([O:60][CH3:59])=[O:101])[O:48][CH:12]=3)=[O:10])[CH2:6]2)[CH2:32][C@@H:31]([CH3:30])[CH2:36][C@@H:76]([O:75][CH3:73])[CH2:81]1

Komponenten

6

Edukt 5

HCID 280Carbon DioxideHCID 3467GentamicinHCID 5961L-GlutamineHCID 225024-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-(2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate, hydrate (1:1:1)HCID 238314-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

Produkt 1

HCID 16115403Neopeltolide

Versuchsvorschrift

All cell lines are maintained in Roswell Park Memorial Institute (RPMI) medium 1640 supplemented with 100 U/mL penicillin 100 μg/ml streptomycin, 60 μg/ml L-glutamine, 18 mM HEPES, 0.05 mg/mL gentamycin and 10% fetal bovine serum. Cell lines are cultured in plastic tissue culture flasks and kept in an incubator at 37° C. in humidified air containing 5% CO2.

Aufarbeitung

  1. temperatureAll cell lines are maintained in Roswell Park Memorial Institute (RPMI) medium 1640
  2. customCell lines are cultured in plastic tissue culture flasks
  3. customkept in an incubator at 37° C. in humidified air

Quellen und Nachweise

ORD-Eintrag
ord-54430c6430da44529262d57f7ce4b87f
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179828B2

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