Acetic Acid → HCID 23061948, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[C-]#[N:13].[K+].C[CH:16]([OH:18])C.C(O)(=O)C>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:13][C:16](=[O:18])[O:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a mixed solution of 1-(3-chlorophenyl)-2-hydroxyethanone (21.8 g), potassium cyanide (20.8 g) and 2-propanol (100 mL) was added acetic acid (18 mL) at room temperature. After stirring for 30 min, water was added, and the precipitated crystals were collected by filtration and recrystallized from methanol-diisopropyl ether to give 4-(3-chlorophenyl)oxazol-2(3H)-one (6.7 g, yield 41%) as a solid.
Aufarbeitung
- filtrationthe precipitated crystals were collected by filtration
- customrecrystallized from methanol-diisopropyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-a9e8cc26de6e4b78b32beb6c7e737c38
- Quelldatensatz
- uspto-grants-2007_02
- Patentnummer
- US07183276B2
Notizen zur Reaktion
Wird geladen…