Ethyl Acetate → HCID 22217916, Verbindung

HRID 351672Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351672
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[C:9](CCCO)#[N:10].[CH3:15][Si](C)(C)[N-][Si](C)(C)C.[Na+].CCO[C:28]([CH3:30])=[O:29]>CS(C)=O>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([O:29][CH2:28][CH:30]([C:9]#[N:10])[CH3:15])=[N:3][CH:4]=1

Komponenten

6

Edukt 4

HCID 8857Ethyl AcetateHCID 693532,5-DibromopyridineHCID 2207054-HydroxybutanenitrileHCID 2724254Sodium bis(trimethylsilyl)amide

Produkt 1

HCID 22217916HCID 22217916, VerbindungAusbeute 39,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

To 2,5-dibromopyridine (500 mg, 2.1 mmol) and 3-cyano-1-propanol (270 mg, 3.1 mmol) in DMSO (2 mL) was added IM sodium hexamethyldisilazide (2.1 mL, 2.1 mmol). The reaction was stirred at room temperature overnight. EtOAc was added to the reaction and the mixture was washed with water (2×10 mL). The EtOAc fraction was dried over anhydrous sodium sulfate and evaporated on a rotary evaporator. The crude product was purified by flash column chromatography over silica gel using 40%EtOAc/hexanes to give 200 mg of 5-bromo-2-cyanopropyloxypyridine as a pale yellow solid (39.3%).

Aufarbeitung

  1. washthe mixture was washed with water (2×10 mL)
  2. dry with materialThe EtOAc fraction was dried over anhydrous sodium sulfate
  3. customevaporated on a rotary evaporator
  4. customThe crude product was purified by flash column chromatography over silica gel using 40%EtOAc/hexanes

Quellen und Nachweise

ORD-Eintrag
ord-e70688de0e9541db8fb4b5d3afdf585e
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06743788B2

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