Hydrochloric Acid → 4-Aminobenzene-1,3-dioic acid

HRID 352655

Reaktionsgleichung

Reaktionsgleichung von HRID 352655
O[Li].O.[NH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11]C)=[O:10])=[CH:7][C:6]=1[C:15]([O-:17])=[O:16].Cl>O1CCOCC1.O>[NH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[C:15]([OH:17])=[O:16]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 225917271,3-Benzenedicarboxylic acid, 4-amino-, 1-methyl ester

Produkt 1

HCID 113558524-Aminobenzene-1,3-dioic acidAusbeute 95,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

6.3 g (150 mmol) of LiOH.H2O are added to a stirred solution of 15.7 g (75 mmol) of methyl 4-amino-isophtalate in 300 ml of dioxane and 1200 ml of water. The reaction mixture is heated for 1 hour to 100° C., cooled and acidified to pH=1 by the addition of concentrated HCl. A precipitate is obtained then filtered off, washed, and dried under vacuum to yield 13 g (yield=95.7%) of the desired compound.

Aufarbeitung

  1. temperatureThe reaction mixture is heated for 1 hour to 100° C.
  2. temperaturecooled
  3. customA precipitate is obtained
  4. filtrationthen filtered off
  5. washwashed
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-78088589acad47cca89cd3e3791a19bc
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06747147B2

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