Methanol → 1,3-Diacetoxyacetone

HRID 356808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 356808
C1O[C:5]([OH:9])([CH2:7][OH:8])[CH2:4][O:3][C:2]1([OH:12])[CH2:10]O.[C:13](OC(=O)C)(=[O:15])[CH3:14].CO>CN(C1C=CN=CC=1)C.N1C=CC=CC=1>[C:13]([O:8][CH2:7][C:5]([CH2:4][O:3][C:2](=[O:12])[CH3:10])=[O:9])(=[O:15])[CH3:14]

Komponenten

6

Edukt 3

HCID 887MethanolHCID 7918Acetic AnhydrideHCID 4180364Dihydroxyacetone dimer

Produkt 1

HCID 2434181,3-Diacetoxyacetone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 1049PyridineLösungsmittel

Versuchsvorschrift

Under an atmosphere of argon, 90 g of 1,3-dihydroxyacetone dimer and 250 mg of 4-(N,N-dimethylamino)pyridine were dissolved in 250 ml of pyridine. To the resulting solution, 225 ml of acetic anhydride was added droopowise at room temperature over 1 hour. After the resulting liquid was stirred at room temperature for 30 minutes, thereto was added 50 ml of methanol and the resulting liquid was further stirred at room temperature for 30 minutes. The solvent was removed under reduced pressure and the residue was subjected to a recrystallization from ether-petroleum ether to give 190 g of the desired compound.

Aufarbeitung

  1. stirringthe resulting liquid was further stirred at room temperature for 30 minutes
  2. customThe solvent was removed under reduced pressure
  3. customthe residue was subjected to a recrystallization from ether-petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-33d87c0372054796ae65535c31a4f149
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05840553

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