Hydroxyamine hydrochloride → 1-Acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime

HRID 35709

Reaktionsgleichung

Reaktionsgleichung von HRID 35709
[C:1]([C:4]1([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH2:7][CH2:6][CH2:5]1)(=O)[CH3:2].Cl.[NH2:17][OH:18].O.O.O.C([O-])(=O)C.[Na+]>O>[C:1](=[N:17][OH:18])([C:4]1([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH2:7][CH2:6][CH2:5]1)[CH3:2]

Komponenten

5

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 130831391-Acetyl-1-(3,4-dichlorophenyl)cyclobutaneHCID 23665404Sodium Acetate Trihydrate

Produkt 1

HCID 860311131-Acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A mixture of 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane (4.86 g) prepared as described in Example 1, hydroxylamine hydrochloride (1.6 g), sodium acetate trihydrate (3.3 g), industrial methylated spirit (15 ml) and water (2 ml) was heated under reflux for twenty hours. The cooled reaction mixture was poured into water and the oil which separated was cooled to give a solid which was recrystallised from industrial methylated spirit to give 1-acetyl-1-(3,4-dichlorophenyl)cyclobutane oxime (m.p. 120°-121° C.).

Aufarbeitung

  1. customprepared
  2. temperaturewas heated
  3. temperatureunder reflux for twenty hours
  4. customThe cooled reaction mixture
  5. customthe oil which separated
  6. temperaturewas cooled
  7. customto give a solid which
  8. customwas recrystallised from industrial methylated spirit

Quellen und Nachweise

ORD-Eintrag
ord-212ada1503ca49f38c304579d022218a
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04767790

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