Water → Ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate

HRID 358024Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 358024
Br.[CH:2]1[N:6]2[C:7]3[C:12]([N:13]=[CH:14][C:5]2=[N:4][C:3]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=3.[BH4-].[Na+].O>C(O)C>[CH:2]1[N:6]2[C:7]3[C:12]([NH:13][CH2:14][C:5]2=[N:4][C:3]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=3

Komponenten

5

Edukt 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 20450288HCID 20450288, Verbindung

Produkt 1

HCID 13228326Ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylateAusbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 1.6 g of ethyl imidazo[1,2-a]quinoxaline-2-carboxylate hydrobromide (British patent application Ser. No. 79-26597, in 50 ml of ethanol was added portionwise 0.5 g of sodium borohydride and at the completion of the reaction (tlc), the mixture was poured into 250 ml of water. The mixture was extracted with ethyl acetate and the organic layer was washed with water, dried and evaporated to dryness to obtain 1.2 g (97% yield) of ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate melting at 206°-8° C.

Aufarbeitung

  1. customat the completion of the reaction (tlc)
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe organic layer was washed with water
  4. customdried
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-2947693e804a48768ca870206a4868c0
Quelldatensatz
uspto-grants-1984_08
Patentnummer
US04464373

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