U 99363 → 4-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine

HRID 361813

Reaktionsgleichung

Reaktionsgleichung von HRID 361813
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:24])[C:15]2[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:24][N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[C:15]1[C:20]([O:21][CH2:22][CH3:23])=[CH:19][CH:18]=[CH:17][N:16]=1

Komponenten

5

Edukt 2

HCID 133107U 99363HCID 2723923Ammonium formate

Produkt 1

HCID 108473684-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1-benzyl-4-[N-methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine (EXAMPLE 70, 1.40 g), palladium-on-carbon (10%, 1.4 g) and ammonium formate (813 mg) in methanol (25 ml) is degassed, stirred at 65° for 45 min, cooled to 20°-25°, and filtered to remove catalyst. The filtrate is concentrated under reduced pressure to give the title compound, NMR (CDCl3) 7.83, 6.97, 6.71, 4.02, 3.88, 3.15, 2.88, 2.63, 1.75 and 1.46δ.

Aufarbeitung

  1. customis degassed
  2. temperaturecooled to 20°-25°
  3. filtrationfiltered
  4. customto remove catalyst
  5. concentrationThe filtrate is concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4794e628ec764be1bb45fce4998378a0
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866589

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