Glycine → Glycine, N-dodecyl-

HRID 36316

Reaktionsgleichung

Reaktionsgleichung von HRID 36316
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].C(N(CC)CC)C.Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>CC(O)C.O>[CH2:25]([NH:1][CH2:2][C:3]([OH:5])=[O:4])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH3:14]

Komponenten

6

Edukt 3

HCID 750GlycineHCID 8471TriethylamineHCID 89191-Bromododecane

Produkt 1

HCID 16771Glycine, N-dodecyl-Ausbeute 26,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Glycine was dissolved in a 2:1 mixture by volume of IPA and water. Triethylamine and 1-bromododecane were added to the solution successively and the mixture was kept stirring for more than 7 days. After the solvent was removed, THF was added to the remaining material. Triethylamine hydrobromide was removed by filtration and the filtrate was concentrated. N-n-dodecylglycine was obtained from the concentrated solution by separation and purification by column chromatography with the yield of 26.3%.

Aufarbeitung

  1. customAfter the solvent was removed
  2. additionTHF was added to the remaining material
  3. customTriethylamine hydrobromide was removed by filtration
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-2d8987052d2b49178f764ccb79a5ad51
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05413794

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