Water → HCID 86740955, Verbindung

HRID 364629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364629
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]2[CH:15]=[N:14][CH:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1.Cl.[NH2:18][OH:19].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:18][OH:19])[CH2:9][C:10]2[CH:15]=[N:14][CH:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 2385124'-Chloro-2-(2-pyrazinyl)-acetophenoneHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 86740955HCID 86740955, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

10 g of 4'-chloro-2-(2-pyrazinyl)-acetophenone, 10 g of hydroxylamine hydrochloride and 12 g of anhydrous sodium carbonate are stirred at 60° in 100 ml of ethanol for 2 hours. The mixture is then treated with water and extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and subsequently concentrated. The residue is crystallized from acetone/n-hexane to yield 4'-chloro-2-(2-pyrazinyl)-acetophenone oxime, m.p. 134°.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialthe organic phase is dried over sodium sulfate
  3. concentrationsubsequently concentrated
  4. customThe residue is crystallized from acetone/n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-88ab50000d52441ebfc6eb4441d5dce2
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04605656

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