Ammonium formate → 1-(Piperazin-1-yl)isoquinoline

HRID 365294Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 365294
C([O-])=O.[NH4+].C([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][N:19]=2)[CH2:14][CH2:13]1)C1C=CC=CC=1>CO.[Pd]>[N:15]1([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][N:19]=2)[CH2:14][CH2:13][NH:12][CH2:17][CH2:16]1

Komponenten

5

Edukt 2

HCID 2723923Ammonium formateHCID 224680261-[4-Benzyl-(1-piperazinyl)]isoquinoline

Produkt 1

HCID 158874361-(Piperazin-1-yl)isoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

Ammonium formate (1.01 g, 16.0 mmol) and 10% Pd/C 42.5 mg, 0.4 mmol, 10 mol%) were added successively to a stirred solution of the product of Example 21 (1.23 g, 4.06 mmol) in methanol (4 ml). The mixture was stirred at room temperature for 6 h and was heated at 75° C. for 16 h. Methanol (40 ml) was added and the mixture filtered through Kieselguhr, and concentrated in vacuo to give the product as a pale yellow oil.

Aufarbeitung

  1. temperaturewas heated at 75° C. for 16 h
  2. filtrationthe mixture filtered through Kieselguhr
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-568fb293b9284b7c90b0164facd81129
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06127357

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