Acetic Acid → 6-Amino-5-nitroso-1,3-dipropylpyrimidine-2,4(1H,3H)-dione

HRID 3654

Reaktionsgleichung

Reaktionsgleichung von HRID 3654
[CH2:1]([N:4]1[C:11]([NH2:12])=[CH:10][C:8](=[O:9])[N:7]([CH2:13][CH2:14][CH3:15])[C:5]1=[O:6])[CH2:2][CH3:3].C(O)(=O)C.[N:20]([O-])=[O:21].[Na+].Cl>O>[CH2:1]([N:4]1[C:11]([NH2:12])=[C:10]([N:20]=[O:21])[C:8](=[O:9])[N:7]([CH2:13][CH2:14][CH3:15])[C:5]1=[O:6])[CH2:2][CH3:3]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 8550556-Amino-1,3-dipropyluracilHCID 23668193Sodium Nitrite

Produkt 1

HCID 51820186-Amino-5-nitroso-1,3-dipropylpyrimidine-2,4(1H,3H)-dioneAusbeute 146,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

1,3-Di-n-propyl-6-aminouracil (30 g) was suspended in 1 L of water with 41 ml of 20% acetic acid and overhead stirring. Sodium nitrite (9.03 g) in 41 ml of water was added in portions, keeping the solution acidic with 12 ml of concentrated hydrochloric acid. A purple precipitate formed. Addition was complete in 10 minutes and the suspension was allowed to stir for 2 hours. The solution was then filtered, and the filtrate was rinsed with water and dried under vacuum to yield 46 g of 1,3-di-n-propyl-5-nitroso-6-aminouracil.

Aufarbeitung

  1. customA purple precipitate formed
  2. additionAddition
  3. stirringto stir for 2 hours
  4. filtrationThe solution was then filtered
  5. washthe filtrate was rinsed with water
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9c11192e28cf449f8f4481cc2630305b
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05734052

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