Water → N-(4-iodophenyl)-2-methylpropanamide

HRID 3667

Reaktionsgleichung

Reaktionsgleichung von HRID 3667
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17].O>C(#N)C>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 1049PyridineHCID 108934-IodoanilineHCID 62325Isobutyryl chloride2×

Produkt 1

HCID 836020N-(4-iodophenyl)-2-methylpropanamideAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a dispersion of p-iodoaniline (219.0 g, 1 mol) in acetonitrile(1000 ml) was added pyridine (81.0 ml, 1 mol). Isobutyryl chloride (100.5 ml, 1 mol) was added dropwise to the mixture over 1 hour in an ice bath. The mixture was further stirred for one hour following the addition of isobutyryl chloride and to the mixture was added water (3000 ml). Precipitated crystalline solids were collected by filtration to give N-(4-iodophenyl)isobutyramide (281.7 g, Yield: 97%).

Aufarbeitung

  1. filtrationPrecipitated crystalline solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-1e9f35d9308c4443ac4377883641dd28
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05734063

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