Carbon Dioxide → 4-Bromo-3-thenoic acid

Temperatur

-78 °C

To a solution of 3,4-dibromothiophene (15 g, 62 mmol) in 80 mL ether under a positive nitrogen atmosphere was added dropwise 75 mL 1.7M t-BuLi in pentane at below -73° C. and the resulting reaction solution was stirred at -78° C. for 0.5 h. After that, the ether solution was poured into dry ice and extracted with water. The aq solution was washed with ether and then acidified with concentrated HCl. The solid was filtered and air-dried to give 9 g of 4-bromo-3-thiophenecarboxylic acid, yield 70.3%.

1. customthe resulting reaction solution
2. extractionextracted with water
3. washThe aq solution was washed with ether
4. filtrationThe solid was filtered
5. customair-dried

ORD-Eintrag

ord-6212e6e68c5b487ea0df8610456e50d7

Quelldatensatz

uspto-grants-2000_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06133252