Water → 3-Methanesulphonyloxy-1-(N-p-nitrobenzyloxycarbonylacetimidoyl)pyrrolidine

HRID 37014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 37014
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7](=[N:9][C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=2)=[O:11])[CH3:8])[CH2:3]1.[CH3:23][S:24](Cl)(=[O:26])=[O:25].C(N(CC)CC)C.O>C(Cl)Cl>[CH3:23][S:24]([O:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7](=[N:9][C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=2)=[O:11])[CH3:8])[CH2:3]1)(=[O:26])=[O:25]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 541832563-hydroxy-1-(N-p-nitrobenzyloxycarbonylacetimidoyl)pyrrolidine

Produkt 1

HCID 539971713-Methanesulphonyloxy-1-(N-p-nitrobenzyloxycarbonylacetimidoyl)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 32.2 g of 3-hydroxy-1-(N-p-nitrobenzyloxycarbonylacetimidoyl)pyrrolidine in 500 ml of methylene chloride, were added, with ice-cooling, 9.3 ml of methanesulphonyl chloride, followed by 16.7 ml of triethylamine. The mixture was stirred for 30 minutes, with ice-cooling, and then water was added, after which the mixture was extracted with methylene chloride and the extract was washed with water and dried, to give 36 g of the title compound.

Aufarbeitung

  1. temperaturecooling
  2. temperaturecooling
  3. extractionafter which the mixture was extracted with methylene chloride
  4. washthe extract was washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-990140d1b6794a5dba00262ab945cfb6
Quelldatensatz
uspto-grants-1995_05
Patentnummer
USRE034960

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