Acetic Acid → 6-(2-Hydroxyphenyl)-3(2H)-pyridazinone

HRID 370752Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 370752
O[CH:2]([CH2:6][C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])[C:3](O)=[O:4].[NH3:16].[NH2:17]N.C(O)(=O)C>O>[OH:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:7]1[CH:6]=[CH:2][C:3](=[O:4])[NH:16][N:17]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 222Ammonia2×HCID 9321HydrazineHCID 13778436HCID 13778436, Verbindung

Produkt 1

HCID 30173466-(2-Hydroxyphenyl)-3(2H)-pyridazinoneAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirred suspension of 2-hydroxy-4-oxo-4-(2-hydroxyphenyl)butyric acid in water was added ammonia until pH 7.0 was attained. Hydrazine was added slowly with the concurrent addition of sufficient glacial acetic acid to maintain a pH of 7.0. Steam heating was applied for 2 hours and during this time the pH of 7.0 was maintained by the addition of ammonia as necessary. The reaction mixture was allowed to cool to room temperature. The solid was filtered off, washed with water, 2-propanol and dried (MgSO4) to afford 6-(2-hydroxyphenyl)-3(2H)-pyridazinone (85%).

Aufarbeitung

  1. temperatureto maintain a pH of 7.0
  2. temperatureSteam heating
  3. filtrationThe solid was filtered off
  4. washwashed with water, 2-propanol
  5. dry with materialdried (MgSO4)

Quellen und Nachweise

ORD-Eintrag
ord-caf4335781aa4d75bb4cdf7359c0a5b8
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04528371

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