Ammonia → 6-(2-Hydroxyphenyl)-3(2H)-pyridazinone

HRID 370753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 370753
O[CH:2]([CH2:6][C:7](=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])[C:3](O)=[O:4].Cl.[NH2:17][NH2:18].N>O.C(O)(=O)C.C(N(CC)CC)C>[OH:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:7]1[CH:6]=[CH:2][C:3](=[O:4])[NH:17][N:18]=1

Komponenten

8

Edukt 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 9321HydrazineHCID 13778436HCID 13778436, Verbindung

Produkt 1

HCID 30173466-(2-Hydroxyphenyl)-3(2H)-pyridazinoneAusbeute 78,3 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a stirred suspension of 2-hydroxy-4-oxo-4-(2-hydroxyphenyl)butyric acid (0.025M) in water (20 ml) was added triethylamine (3.3 ml), taking the pH to 9.5, followed by concentrated hydrochloric acid (2.5 ml) to take the pH to 4. Hydrazine (0.05M) was added slowly with the concurrent addition of sufficient glacial acetic acid to maintain a pH of 7.0. Steam heating was applied for 2 hours and during this time the pH of 7.0 was maintained by the addition of ammonia as necessary. The reaction mixture was allowed to cool to room temperature. The solid was filtered off, washed with water, 2-propanol and dried to afford 6-(2-hydroxyphenyl)-3(2H)-pyridazinone (78.3%).

Aufarbeitung

  1. temperatureto maintain a pH of 7.0
  2. temperatureSteam heating
  3. filtrationThe solid was filtered off
  4. washwashed with water, 2-propanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-77b26cc6ff1148b685509d4ad536726f
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04528371

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