Hydrochloric Acid → 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride

HRID 37087

Reaktionsgleichung

Reaktionsgleichung von HRID 37087
[F:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:11]1=[N:12][CH:13]=[N:14][C:15]=2[NH2:19].C(O)(C)C.[ClH:24]>CO.O>[ClH:24].[F:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:11]1=[N:12][CH:13]=[N:14][C:15]=2[NH2:19]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 1002532'-Fluoro-2'-deoxyadenosine

Produkt 1

HCID 677407569-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)adenine (500 mg. 1.86 mmol) in MeOH (40 ml) and water (10 ml) was added a solution of isopropanol (15 ml) previously saturated with HCl gas. The solution was evaporated under vacuum at room temperature, and triturated with EtOH (25 ml) to afford the title compound as a white solid.

Aufarbeitung

  1. customThe solution was evaporated under vacuum at room temperature
  2. customtriturated with EtOH (25 ml)

Quellen und Nachweise

ORD-Eintrag
ord-6f3bdcf96f5c441380f7fe1672130045
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05420115

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