6-Methyluracil → 2,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-

HRID 371455

Reaktionsgleichung

Reaktionsgleichung von HRID 371455
[Br:1]Br.[CH3:3][C:4]1[NH:9][C:8](=[O:10])[NH:7][C:6](=[O:11])[CH:5]=1>C(O)(=O)C>[Br:1][C:5]1[C:6](=[O:11])[NH:7][C:8](=[O:10])[NH:9][C:4]=1[CH3:3]

Komponenten

4

Edukt 2

HCID 122836-MethyluracilHCID 24408Bromine

Produkt 1

HCID 847572,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-Ausbeute 77,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Bromine (39.97 g, 0.25 mole) was added dropwise to a cooled mixture of 31.5 g (0.25 mole) of 6-methyl-2,4(1H,3H)pyrimidinedione in 200 ml of glacial acetic acid. The resulting mixture was stirred at ambient temperature for 16 hours and then filtered. The solid which was collected was washed with water and dried in vacuo overnight at 69° C. to give 39.9 g of the product as a white solid, mp 254° C. (dec.).

Aufarbeitung

  1. filtrationfiltered
  2. customThe solid which was collected
  3. washwas washed with water
  4. customdried in vacuo overnight at 69° C.

Quellen und Nachweise

ORD-Eintrag
ord-75d36cdee415432186b42c2d574b37a0
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04532240

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