Acetic Acid → Methyl 3-quinolinecarboximidate

HRID 374182Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 374182
[C:1]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2)#[N:2].C[O-].[Na+].[C:16](O)(=[O:18])C>CO>[N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=[C:3]([C:1](=[NH:2])[O:18][CH3:16])[CH:4]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 931773-QuinolinecarbonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 19734518Methyl 3-quinolinecarboximidate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3-cyanoquinoline (1.58 g, 10.2 mmol) was dissolved in methanol (20 ml), and sodium methoxide (0.06 g, 1.1 mmol) was added. The reaction was conducted at room temperature for 22 hours. After the reaction was completed, acetic acid (0.07 g, 1.1 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (60 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 3-quinolinecarboximidate.

Aufarbeitung

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (60 ml) was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e3375ed382f2409f97ed00b2d5b32f62
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05166347

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