Acetic Acid → Methyl furan-2-carboximidate

2-Cyanofuran (4.50 g, 48.3 mmol) was dissolved in methanol (25 ml), and sodium methoxide (130 mg, 2.4 mmol) was added under ice-cooling. The mixture was stirred while the temperature is slowly raised up to room temperature for 2 hours. After the reaction was completed, acetic acid (0.16 g, 2.6 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (100 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-furancarboximidate (6.0 g) as a pale yellow oil.

1. temperaturecooling
2. concentrationthe solution was concentrated under reduced pressure
3. additionDiethyl ether (100 ml) was added to the concentrated residue, and insolubles
4. customwere removed by filtration
5. concentrationThe filtrate was concentrated under reduced pressure

ORD-Eintrag

ord-d7557f1185924eb993592fd29bf48f31

Quelldatensatz

uspto-grants-1992_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05166347