Acetic Acid → Methyl 2-thiophenecarboximidate

HRID 374193Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 374193
[C:1]([C:3]1[S:4][CH:5]=[CH:6][CH:7]=1)#[N:2].C[O-].[Na+].[C:11](O)(=[O:13])C>CO>[S:4]1[CH:5]=[CH:6][CH:7]=[C:3]1[C:1](=[NH:2])[O:13][CH3:11]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 660872-ThiophenecarbonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 398427Methyl 2-thiophenecarboximidateAusbeute 817,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-cyanothiophene (5.46 g, 50 mmol) was dissolved in methanol (25 ml), and sodium methoxide (0.27 g, 5 mmol) was added. The mixture was stirred at room temperature for 18 hours. After the reaction was completed, acetic acid (0.33 g, 5.5 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (40 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-thiophenecarboximidate (6.35 g) as a yellow oil.

Aufarbeitung

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (40 ml) was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8cf7d2e265df4e02b61ed7c7f849188d
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05166347

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