Bromine → 2-(Bromoacetyl)-5-chlorothiophene

HRID 374523

Reaktionsgleichung

Reaktionsgleichung von HRID 374523
[Br:1]Br.[C:3]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4].CCOCC.CCCCCC>C(Cl)(Cl)Cl.O>[Br:1][CH2:4][C:3]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)=[O:5]

Komponenten

6

Edukt 3

HCID 24408BromineHCID 805722-Acetyl-5-chlorothiopheneHCID 21584099Diethylether hexane

Produkt 1

HCID 20636342-(Bromoacetyl)-5-chlorothiopheneAusbeute 43,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

A solution of bromine (18.90 g, 118 mmol) in chloroform is added to a solution of 2-acetyl-5-chlorothiophene (19.00 g, 118 mmol) in chloroform at 40°-45° C. The reaction mixture is stirred at room temperature for two hours and diluted with water. The organic layer is separated, dried over MgSO4 and concentrated in vacuo to give a solid. The solid is slurried in an ether/hexane solution, filtered and dried to give the title product as a solid (12.20 g, mp 68°-70° C.).

Aufarbeitung

  1. customThe organic layer is separated
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated in vacuo
  4. customto give a solid
  5. filtrationfiltered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c3a9920f6fd74ed38401012bf093bc09
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05480902

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