Acetic Anhydride → N-(hydroxymethyl)acetamide acetate

HRID 375179

Reaktionsgleichung

Reaktionsgleichung von HRID 375179
[C:1]([O:4]C(=O)C)(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>N1C=CC=CC=1>[C:1]([OH:4])(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 69365Formicin

Produkt 1

HCID 86745977N-(hydroxymethyl)acetamide acetateAusbeute 900 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineKatalysator

Versuchsvorschrift

Acetic anhydride (25 g) and pyridine (10 drops) is added to N-(hydroxymethyl)acetamide (9 g, 0.1 mol). The reaction mixture is stirred overnight at room temperature, concentrated in vacuo and chased with xylene to give the title product as an oil (11.9 g, 0.9 mol) which is identified by 1HNMR spectral analysis.

Aufarbeitung

  1. concentrationconcentrated in vacuo and chased with xylene

Quellen und Nachweise

ORD-Eintrag
ord-452be2e369b949f39458cfbb65e5b732
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05484807

Verknüpfte Notizen

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