Water → Methyl 6-formylpyridine-2-carboxylate

HRID 376298

Reaktionsgleichung

Reaktionsgleichung von HRID 376298
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][OH:12])[N:6]=1)=[O:4].O>ClCCCl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]=[O:12])[N:6]=1)=[O:4]

Komponenten

5

Edukt 2

HCID 962WaterHCID 11513809Methyl 6-(hydroxymethyl)picolinate

Produkt 1

HCID 12575850Methyl 6-formylpyridine-2-carboxylateAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

A solution of 3 g of 6-hydroxymethylpyridine-2-carboxylic acid methyl ester (16.5 mmol) in 70 ml of 1,2-dichloroethane containing 15 g of manganese dioxide (165 mmol) is heated under reflux for 4 hours with removal of the water formed continuously. The solid is removed by filtration on celite and then the dichloromethane is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 70:30). 2.33 g of a yellow oil are recovered.

Aufarbeitung

  1. customformed continuously
  2. customThe solid is removed by filtration on celite
  3. customthe dichloromethane is evaporated off

Quellen und Nachweise

ORD-Eintrag
ord-7eeb93095125479cbb6978ebce1004e3
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020345

Verknüpfte Notizen

Wird geladen…