Water → (S)-2-Acetylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid

HRID 376405Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 376405
[NH2:1][C@@H:2]([CH2:6][C:7]([C:9]1[CH:21]=[CH:20][C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[CH:10]=1)=[O:8])[C:3]([OH:5])=[O:4].O.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C@@H:2]([CH2:6][C:7]([C:9]1[CH:21]=[CH:20][C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[CH:10]=1)=[O:8])[C:3]([OH:5])=[O:4])(=[O:25])[CH3:24]

Komponenten

4

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 53753679(S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid

Produkt 1

HCID 53666229(S)-2-Acetylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid

Versuchsvorschrift

A suspension of (S)-2-amino-4-dibenzofuran-2-yl-4-oxo-butyric acid (0.025 g, 0.000082 mol) obtained above in Example 3 in acetic anhydride (2 mL) and water (4 mL) was sonicated (Cole Parmer 8850 Ultrasound Bath) for 15 minutes at room temperature. The resulting solution was then concentrated in vacuo, and the resulting residue was recrystallized from ethyl acetate/diethyl ether (50:50, v/v) to yield the title product as a white solid; mp 166-170° C.

Aufarbeitung

  1. concentrationThe resulting solution was then concentrated in vacuo
  2. customthe resulting residue was recrystallized from ethyl acetate/diethyl ether (50:50

Quellen und Nachweise

ORD-Eintrag
ord-cc612f1cba554f73be4d2dd05f786133
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020366

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