Tetrahydrofuran → 5'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl

HRID 376448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 376448
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:16]=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][C:11](SC)=[CH:10][CH:9]=2)[CH:7]=1.O[O:19][S:20]([O-:22])=O.[K+].[CH2:24]1COCC1>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:16]=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:20]([CH3:24])(=[O:22])=[O:19])=[CH:10][CH:9]=2)[CH:7]=1

Komponenten

6

Edukt 3

HCID 8028TetrahydrofuranHCID 193619465'-Fluoro-2'-Formyl-4-MethylthiobiphenylHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 193619415'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 94433Tetrabutylammonium hydrogen sulfateKatalysatorHCID 962WaterLösungsmittel2×

Versuchsvorschrift

5'-Fluoro-2'-formyl-4-methylthiobiphenyl (10 mmol) (Example 1E) in THF (20 ml) is charged dropwise with oxone® (6 mmol) and tetrabutylammonium hydrogensulfate (1 mmol) in water (15 ml). The mixture is stirred at room temperature for 1 hour. The suspension is poured into water (300 ml), the precipitate is filtered off, is washed with water and is dried in vacuo to give the title product.

Aufarbeitung

  1. filtrationthe precipitate is filtered off
  2. washis washed with water
  3. customis dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-382c66dc8b9d4744a64ecbb415b1b451
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020379

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