Water → 2-[2-[(3-Methoxyphenyl)methyl]cyclohexyl]-4,5-diphenyloxazole

HRID 377299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 377299
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]2[C:16]([O:18][CH:19]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:20](=O)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=O)[CH:6]=[CH:7][CH:8]=1.C([O-])(=O)C.[NH4+:38].O.ClCCl>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]2[C:16]2[O:18][C:19]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:38]=2)[CH:6]=[CH:7][CH:8]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6344DichloromethaneHCID 517165Ammonium AcetateHCID 542348532-Oxo-1,2-diphenylethyl 2-[(3-methoxy-phenyl)methyl]cyclohexanecarboxylate

Produkt 1

HCID 193584162-[2-[(3-Methoxyphenyl)methyl]cyclohexyl]-4,5-diphenyloxazoleAusbeute 93,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 2-oxo-1,2-diphenylethyl 2-[(3-methoxy-phenyl)methyl]cyclohexanecarboxylate (440 mg) and ammonium acetate (593 mg) in acetic acid (2.4 ml) was refluxed for 3 hours and cooled to room temperature, and a mixture of water and dichloromethane was added thereto. The organic layer was washed with water and sodium bicarbonate aqueous solution, dried over magnesium sulfate, and evaporated in vacuo to afford 2-[2-[(3-methoxyphenyl)methyl]cyclohexyl]-4,5-diphenyloxazole (394 mg).

Aufarbeitung

  1. additionwas added
  2. washThe organic layer was washed with water and sodium bicarbonate aqueous solution
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-30e180bced7d4a37807ea11899456731
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06025375

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