Water → 5-Chloro-1-benzofuran-2-carbaldehyde

LiA1H4 (3.04 g, 80 mmol) was suspended under stirring at 0° under Ar in anhydrous THF (150 ml), then N-methylpiperazine dihydrochloride (6.92 g, 40 mmol) was added portionwise in 10 minutes. N-methylpiperazine (12 g, 120 mmol) was then added dropwise, the mixture was warmed to RT and stirring continued for 2 hours. The surnatant of this suspension was then added by syringe to a stirred solution at 0° under Ar of 5-chlorobenzofuran-2-carboxylic acid (2.95 g, 15.0 mmol) in anhydrous THF (50 ml). The mixture was refluxed for 4 hours and after cooling to RT the suspension was diluted with Et2O (400 ml). The resulting mixture was poured into water (500 ml) and the organic phase was decanted. The aqueous phase was extracted with Et2O (2×300 ml) and the pooled organic extracts were washed with 2N NaOH (200 ml), 1N HCl (200 ml) and brine (200 ml). After drying (MgSO4) and concentration a brown oily residue was obtained. This was chromatographed on silicagel (n-heptane/EtOAc 3/1). The pooled fractions produced after evaporation pure title compound (850 mg, 4.71 mmol, yield 31.4%) as brown needles.

1. temperatureThe mixture was refluxed for 4 hours
2. temperatureafter cooling to RT the suspension
3. customthe organic phase was decanted
4. extractionThe aqueous phase was extracted with Et2O (2×300 ml)
5. washthe pooled organic extracts were washed with 2N NaOH (200 ml), 1N HCl (200 ml) and brine (200 ml)
6. customAfter drying
7. concentration(MgSO4) and concentration a brown oily residue
8. customwas obtained
9. customThis was chromatographed on silicagel (n-heptane/EtOAc 3/1)
10. customThe pooled fractions produced

ORD-Eintrag

ord-c4592dbbbd07401993106dd98d202690

Quelldatensatz

uspto-grants-2000_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06025390