Dichloromethane → Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate

HRID 377917Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 377917
[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH2:6])=[C:4]([O:10][CH3:11])[CH:3]=1.C(Cl)Cl.Cl[C:16]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17]>O>[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH:6][C:16](=[O:17])[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:4]([O:10][CH3:11])[CH:3]=1

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 15891Phenyl chloroformateHCID 193571402-Methoxy-4,5-dimethylaniline

Produkt 1

HCID 19357180Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 4,5-dimethyl-2-methoxyaniline(4.50 g, 0.03 mol), methylene chloride(100 ml) was added and phenyl chloroformate(4.80 g, 0.03 mol) was added slowly. The resulting solution was stirred for 2 hrs and thereto water(150 ml) was added, and extracted with methylene chloride and purified by column chromatography to obtain the titled compound.

Aufarbeitung

  1. extractionextracted with methylene chloride
  2. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9aaedd679882450eacbdbdc42be67a34
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028195

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