Ammonium Hydroxide → 4-Amino-3,5,6-trifluoro-2-cyanopyridine
Reaktionsgleichung
[F:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][C:5]([F:10])=[C:6]([F:9])[C:7]=1F.[OH-].[NH4+:14]>CN(C=O)C.O>[NH2:14][C:7]1[C:6]([F:9])=[C:5]([F:10])[N:4]=[C:3]([C:11]#[N:12])[C:2]=1[F:1]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of 3,4,5,6-tetrafluoro-2-cyanopyridine in DMF (75 mL) at 0C was slowly added concentrated ammonium hydroxide (15 mL). The reaction was stirred and additional 15 min and the solution was diluted with water (150 mL). The solid was collected and air dried to give 4-amino-3,5,6-trifluoro-2-cyanopyridine (25.5 g, 0.16 mol, 92%); mp 291-30 C.
Aufarbeitung
- customThe solid was collected
- customair dried
Quellen und Nachweise
- ORD-Eintrag
- ord-863ffce9f2b545329952788ae4bad168
- Quelldatensatz
- uspto-grants-2001_10
- Patentnummer
- US06297197B1
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