Water → 1-Methylsulfonyloxy-5-phenylpentane

HRID 378973Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 378973
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22].O>C(Cl)Cl>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 615235-Phenyl-1-pentanol

Produkt 1

HCID 116301071-Methylsulfonyloxy-5-phenylpentaneAusbeute 100,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

5-Phenyl-pentanol (40 g, 244 mmoles) in methylene chloride (80 ml) at 0° C. was added with triethylamine (39 ml, 28.34 g, 280 mmoles) and a solution of methyl-sulfonyl chloride (20.7 ml, 30.69 g, 268 mmoles) in methylene chloride (40 ml). The temperature was left to rise to the room value, then the mixture was poured into water and the organic phase was isolated, washed with water, anhydrified and concentrated to give 59.49 g of the title product (yield: 99%).

Aufarbeitung

  1. waitThe temperature was left
  2. customthe organic phase was isolated
  3. washwashed with water, anhydrified
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-23c3cb3c1e2c4f0389ecf98416913ab2
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297257B1

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