Water → 4-Bromo-2,5-difluorobenzenesulfonamide

HRID 380000

Reaktionsgleichung

Reaktionsgleichung von HRID 380000
[OH-].[NH4+:2].[F:3][C:4]1[CH:9]=[C:8]([Br:10])[C:7]([F:11])=[CH:6][C:5]=1[S:12](Cl)(=[O:14])=[O:13].O>O1CCCC1>[Br:10][C:8]1[C:7]([F:11])=[CH:6][C:5]([S:12]([NH2:2])(=[O:14])=[O:13])=[C:4]([F:3])[CH:9]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14923Ammonium HydroxideHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

Produkt 1

HCID 27732934-Bromo-2,5-difluorobenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ammonium hydroxide (5 ml) was added to a solution of 2,5-difluoro-4-bromophenylsulfonyl chloride (4.3 g) in tetrahydrofuran (20 ml) at room temperature (CARE:exotherm) and stirred for 10 min. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate was dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated and the residue triturated with 20% diethyl ether in isohexane to give the sub-title compound as a solid (4.3 g).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customThe filtrate was evaporated
  5. customthe residue triturated with 20% diethyl ether in isohexane

Quellen und Nachweise

ORD-Eintrag
ord-80781d6e4daf441a96141ea53578b925
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06300352B1

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