Acetic Acid → 4-Bromo-2-methylbenzene-1-sulfonamide

HRID 380043Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380043
[Br:1][C:2]1[CH:3]=C([CH:6]=[CH:7][C:8]=1C)N.N([O-])=O.[Na+].Cl.[Cl-].[Mg+2].[Cl-].[S:18](=[O:20])=[O:19].[OH-].[NH4+:22].[C:23](O)(=O)[CH3:24]>[Cu](Cl)Cl>[Br:1][C:2]1[CH:8]=[CH:7][C:6]([S:18]([NH2:22])(=[O:20])=[O:19])=[C:23]([CH3:24])[CH:3]=1

Komponenten

9

Edukt 7

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 14923Ammonium HydroxideHCID 82187Benzenamine, 3-bromo-4-methyl-HCID 5360315Magnesium ChlorideHCID 23668193Sodium Nitrite

Produkt 1

HCID 206167674-Bromo-2-methylbenzene-1-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24014Cupric ChlorideKatalysator

Versuchsvorschrift

Prepared by the method of Example 69a) using 3-bromo-4-methylaniline (2.60 g, Example 78a)), sodium nitrite (1.05 g), concentrated hydrochloric acid (20 ml), anhydrous magnesium chloride (2.6 g), acetic acid saturated with sulfur dioxide (50 ml) and copper (II) chloride (0.37 g). The normal work-up and subsequent treatment with ammonium hydroxide (50 ml) followed by the same work-up afforded the subtitle compound as a solid (1.51 g).

Aufarbeitung

  1. customPrepared by the method of Example 69a)

Quellen und Nachweise

ORD-Eintrag
ord-6eed423eaf45419abf435b98bb927e2c
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06300352B1

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