Pyridine → HCID 9801910, Verbindung

HRID 380572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380572
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([CH2:14][NH2:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:28](Cl)(=[O:37])[C:29]1[C:30]([O:35][CH3:36])=[CH:31][CH:32]=[CH:33][CH:34]=1.CCOCC>CN(C)C1C=CN=CC=1.C(Cl)Cl>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([CH2:14][NH:15][C:28]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])=[O:37])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

7

Edukt 4

HCID 1049PyridineHCID 3283Diethyl EtherHCID 889692-Methoxybenzoyl chlorideHCID 804238(1-Benzyl-4-phenylpiperidin-4-yl)methanamine

Produkt 1

HCID 9801910HCID 9801910, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2.1 g (7.6 mmol) of 1-N-Benzyl-4-phenyl-4-aminomethylpiperidine and 1.2 mL of pyridine (15.2 mmol) and 20 mg of 4-dimethylaminopyridine (DMAP) in 20 mL of methylene chloride was added 2.6 g (15.2 mmol) of o-anisoyl chloride at 0° C. The reaction mixture was stirred for 12 hr and was poured into 200 ml of ether. It was washed with saturated NaHCO3 solution, dried over MgSO4 and concentrated. The residue was purified by chromatography (silica, hexanes: ethyl acetate, 1:4) to afford the title compound.

Aufarbeitung

  1. washIt was washed with saturated NaHCO3 solution
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated
  4. customThe residue was purified by chromatography (silica, hexanes: ethyl acetate, 1:4)

Quellen und Nachweise

ORD-Eintrag
ord-6a00bd75ceaa4ad592af22f4a34b2aab
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303637B1

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