Bromine → 7-Bromo-5-nitroindoline

HRID 380593Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380593
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH2:8][CH2:7]2)([O-:3])=[O:2].[Br:13]Br>CC(O)=O>[Br:13][C:11]1[CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[C:6]2[C:10]=1[NH:9][CH2:8][CH2:7]2

Komponenten

4

Edukt 2

HCID 24408BromineHCID 362195-Nitroindoline

Produkt 1

HCID 3234907-Bromo-5-nitroindolineAusbeute 131,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a solution of 5-nitroindoline (from Aldrich, 2.0 g, 12.2 mmol) in 15 mL of AcOH was added Br2 (1.0 mL, 19.4 mmol) in a portion and the resulting solution was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo, yielding a yellow solid (3.9 g, >95%) of the desired product as a HBr salt, which was subjected to the following reaction without further purification.

Aufarbeitung

  1. customReaction mixture
  2. concentrationwas concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-87da855a29ce4bdbac0e05ec2d22c0fd
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303643B1

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