Diethyl Ether → (2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester

HRID 38259

Reaktionsgleichung

Reaktionsgleichung von HRID 38259
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[C:18]([O:22][C:23](=[O:26])[CH2:24]Br)([CH3:21])([CH3:20])[CH3:19].C(OCC)C>CN(C=O)C.O>[C:8]([C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[O:11][CH2:24][C:23]([O:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:26])(=[O:10])[CH3:9]

Komponenten

7

Edukt 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 740613-Chloro-6-hydroxyacetophenoneHCID 79177tert-Butyl bromoacetate

Produkt 1

HCID 67131695(2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 1-(5-chloro-2-hydroxyphenyl)-ethanone (2 g), potassium carbonate (1.62 g) and tert-butylbromoacetate (1.73 ml) in DMF (5 ml) was stirred at ambient temperature for 16 h. Diethyl ether and water were added and the organic layer separated, it was washed with water, aqueous potassium carbonate solution, brine, dried (Na2SO4) and the solvent removed in vacuo to give the sub-title compound (2.84 g).

Aufarbeitung

  1. customthe organic layer separated
  2. washit was washed with water, aqueous potassium carbonate solution, brine
  3. dry with materialdried (Na2SO4)
  4. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e58e506d526849c4b183a9ac5b1d2265
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524715B2

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