Water → 4-Carboxy-2-phenylbenzoyl methionine methyl ester

HRID 383102Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 383102
[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:21][CH2:22][S:23][CH3:24])[NH:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][C:10](Br)=[CH:9][C:8]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CCN(CC[O:33][C:34]1C=CC(CC2C=CC=CC=2)=CC=1)CC.Cl.[C]=[O:49].O>CN(C=O)C.CC([O-])=O.CC([O-])=O.[Pd+2]>[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:21][CH2:22][S:23][CH3:24])[NH:5][C:6](=[O:20])[C:7]1[CH:12]=[CH:11][C:10]([C:34]([OH:33])=[O:49])=[CH:9][C:8]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

7

Edukt 4

HCID 962WaterHCID 175534Tesmilifene HydrochlorideHCID 20622824(2-Phenyl4bromobenzoyl)-methionine methyl esterHCID 178418416HCID 178418416, Verbindung

Produkt 1

HCID 206228254-Carboxy-2-phenylbenzoyl methionine methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 167845palladium(II) acetateKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 4-bromo-2-phenylbenzoyl methionine methyl ester (1.0 equivalent), Pd(OAc)2 (0.05 equivalent) and DPPE (1.0 equivalent) is heated in DMF to 65° C. under 4 atm. of carbon monoxide until TLC analysis indicates that the reaction is complete. The reaction mixture is poured into water and extracted with ethyl acetate which is dried and evaporated. The product is purified by chromatography on silica gel.

Aufarbeitung

  1. extractionextracted with ethyl acetate which
  2. customis dried
  3. customevaporated
  4. customThe product is purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-089535082d7644e9af225ebee1e117c6
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310095B1

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