Bromine → Ethyl 3-bromo-4-oxobutanoate

HRID 383111

Reaktionsgleichung

Reaktionsgleichung von HRID 383111
[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH:7]=[O:8])[CH3:2].[Br:10]Br>C(OCC)C>[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH:6]([Br:10])[CH:7]=[O:8])[CH3:2]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 82395Ethyl 4-oxobutanoate

Produkt 1

HCID 15576269Ethyl 3-bromo-4-oxobutanoateAusbeute 66,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a 0-5° C. mechanically-stirred solution in diethyl ether (100 mL) of succinaldehydic acid ethyl ester (10.0 g, 77 mmol) was added bromine (3.9 g, 151 mmol) over 2.5 hours. The reaction mixture was stirred for an additional 1.25 hours and the ether was distilled at atmospheric pressure. The remaining yellow oil was distilled (6.0-6.5 mm Hg, bp 95-101° C.) to give 3-bromosuccinaldehydic acid ethyl ester (10.7 g, 66%).

Aufarbeitung

  1. distillationthe ether was distilled at atmospheric pressure
  2. distillationThe remaining yellow oil was distilled (6.0-6.5 mm Hg, bp 95-101° C.)

Quellen und Nachweise

ORD-Eintrag
ord-e27d267f52fb48c582371c116a9045d5
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310095B1

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