Bromine → 3-Bromo-6-iodoimidazo[1,2-A]pyridine

HRID 383307Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 383307
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[N:6]2[CH:7]=[C:2]([I:1])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 27643276-Iodoimidazo(1,2-a)pyridine

Produkt 1

HCID 684848303-Bromo-6-iodoimidazo[1,2-A]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a mixture comprising 6-iodo-imidazo[1,2-a]pyridine (1 eq, 95 mmol, 23.3 g) in acetic acid (220 ml) under an inert atmosphere of argon is added dropwise bromine (1 eq, 95 mmol, 4.8 ml). After stirring at room temperature for 1 hour, the reaction mixture is filtered. The resulting solid is suspended in DCM (1% MeOH) (500 ml) and washed with 4N sodium hydroxide (100 ml). When the solid dissolves, the organic layer is separated, dried (MgSO4) and evaporated to give a beige solid; [M+H]+323 (325).

Aufarbeitung

  1. filtrationthe reaction mixture is filtered
  2. washwashed with 4N sodium hydroxide (100 ml)
  3. dissolutionWhen the solid dissolves
  4. customthe organic layer is separated
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto give a beige solid

Quellen und Nachweise

ORD-Eintrag
ord-b16d9910126441a4bc47f93ceb23d1eb
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367662B2

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