Lithium hydroxide, monohydrate → Lithium 7-(4-(2-(1-acetylindolin-5-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate

HRID 383823

Reaktionsgleichung

O.[OH-].[Li+:3].[C:4]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][N:21]([C:24]4[C:32]5[O:31][C:30]([C:33]([O:35]CC)=[O:34])=[CH:29][C:28]=5[CH:27]=[CH:26][CH:25]=4)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[CH2:9][CH2:8]1)(=[O:6])[CH3:5]>O1CCCC1.O>[C:4]([N:7]1[C:15]2[C:10](=[CH:11][C:12]([CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][N:21]([C:24]4[C:32]5[O:31][C:30]([C:33]([O-:35])=[O:34])=[CH:29][C:28]=5[CH:27]=[CH:26][CH:25]=4)[CH2:22][CH2:23]3)=[CH:13][CH:14]=2)[CH2:9][CH2:8]1)(=[O:6])[CH3:5].[Li+:3]

Komponenten

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

Lithium hydroxide monohydrate (0.087 g, 2.08 mmol) was added to a solution of ethyl 7-(4-(2-(1-acetylindolin-5-yl)ethyl)piperazin-1-yl)benzofuran-2-carboxylate (0.481 g, 1.04 mmol) in tetrahydrofuran (9 mL) and water (1 mL) and the reaction was heated at 100° C. for 35 min in a microwave oven. The solvents were evaporated and the material was dried in vacuum over P2O5 to give 0.454 g of the crude product. The crude material was used in the next step assuming quantitative yield without further purification. MS (ES+) m/z 434.2 (M+H)+.

Aufarbeitung

customThe solvents were evaporated
dry with materialthe material was dried in vacuum over P2O5

Quellen und Nachweise

ORD-Eintrag: ord-130c86dc8d8f40b6bb24f227a30ab921
Quelldatensatz: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08367676B2

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