5-Amino-3-chloropyrazine-2-carbonitrile → 5-Amino-3-methoxypyrazine-2-carbonitrile

HRID 384721

Reaktionsgleichung

Reaktionsgleichung von HRID 384721
[NH2:1][C:2]1[N:3]=[C:4](Cl)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:11][O-:12].[Na+].CO>CO.O>[NH2:1][C:2]1[N:3]=[C:4]([O:12][CH3:11])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 210753925-Amino-3-chloropyrazine-2-carbonitrileHCID 23694274Sodium methanolate methanol

Produkt 1

HCID 596133845-Amino-3-methoxypyrazine-2-carbonitrileAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

5-Amino-3-chloropyrazine-2-carbonitrile (52 mg, 0.34 mmol) was suspended in NaOMe/MeOH (2M, 2 mL). The reaction mixture was heated at 80° C. for 30 min using microwave irradiation. After cooling, the mixture was diluted with MeOH (3 mL) and water (2 mL). The solvents were concentrated and the resulting precipitate was filtered off, washed with water (3 mL) and dried in vacuo to give the title compound as a yellow solid (33 mg, 58%).

Aufarbeitung

  1. custommicrowave irradiation
  2. temperatureAfter cooling
  3. concentrationThe solvents were concentrated
  4. filtrationthe resulting precipitate was filtered off
  5. washwashed with water (3 mL)
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3f89ef85d9d14031bdc39093f3e5c7a0
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367658B2

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