Hydroxyamine hydrochloride → 4-methoxy-2,3-dihydro-1H-inden-1-one oxime

HRID 384973

Reaktionsgleichung

Reaktionsgleichung von HRID 384973
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=O.[NH2:13][OH:14].Cl.C([O-])(=O)C.[Na+]>CO>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH2:6][C:7]2=[N:13][OH:14]

Komponenten

5

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 45474914-methoxy-2,3-dihydro-1H-inden-1-one

Produkt 1

HCID 766564544-methoxy-2,3-dihydro-1H-inden-1-one oximeAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 4-methoxy-2,3-dihydro-1H-inden-1-one (1.0 g, 1.0 eq.) in 25 ml MeOH was added NH2OH.HCl (0.493 g, 1.15 eq.) and sodium acetate (0.597 g, 1.18 eq.). The resulting mixture was stirred at room temperature overnight. The reaction mixture was diluted with 100 ml ice-water. The white precipitate was collected by filtration, washed with 3×20 ml water and dried in vacuo to afford 1.08 g (yield 99%) 4-methoxy-2,3-dihydro-1H-inden-1-one oxime which was used to next step without further purification.

Aufarbeitung

  1. filtrationThe white precipitate was collected by filtration
  2. washwashed with 3×20 ml water
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d3a87c1c72994cb09db54a91dd7ee20b
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367836B2

Verknüpfte Notizen

Wird geladen…